One key difference between Tadalafil and Sildenafil is their duration of action. Tadalafil has a longer duration of action, which means it stays in the body for a longer period of time. This allows for more spontaneity in sexual activity, as Tadalafil can be taken up to 36 hours before sexual activity. On the other hand, Sildenafil has a shorter duration of action, typically lasting for about 4 to 5 hours.
Another difference is the timing of when they should be taken. Tadalafil can be taken with or without food, while Sildenafil should be taken on an empty stomach for optimal absorption.
Additionally, Tadalafil is often prescribed for the treatment of both erectile dysfunction and symptoms of benign prostatic hyperplasia (BPH), while Sildenafil is primarily used for erectile dysfunction.